FOXO4 is a transcription factor protein associated with the regulation of cellular senescence, belonging to the FOXO (Forkhead box O) family. It plays a key role in delaying aging, suppressing tumors, and maintaining stem cell function by participating in DNA damage repair, oxidative stress response, and cell cycle regulation. Recent studies have found that targeting. 

FOXO4-DRI (FOXO4-p53 interfering peptide) can selectively eliminate senescent cells, offering a novel strategy for anti-aging and treating age-related diseases (such as fibrosis and osteoarthritis), with potential biomedical applications. Research on its mechanisms provides important scientific insights for developing anti-aging drugs and cell regeneration therapies.